Chloroquine delivery to erythrocytes in Plasmodium berghei-infected mice using antibody-bearing liposomes as drug vehicles
Identifieur interne : 002F82 ( Main/Exploration ); précédent : 002F81; suivant : 002F83Chloroquine delivery to erythrocytes in Plasmodium berghei-infected mice using antibody-bearing liposomes as drug vehicles
Auteurs : Subhash Chandra [Inde] ; Ajay K. Agrawal [Inde] ; C. M. Gupta [Inde]Source :
- Journal of Biosciences [ 0250-5991 ] ; 1991-09-01.
English descriptors
- KwdEn :
- Teeft :
- Agrawal, Berghei, Berghei infection, Biophys, Chandra, Chloroquine, Covalently, Encapsulated, Erythrocyte, Gupta, Infection, Kumar, Liposomal, Liposome, Liposome surface, Liposomized, Malarial, Malarial infection, Malarial infections, Parasitaemia, Plasmodium, Resistant infections, Singhal, Subhash, Subhash chandra.
Abstract
Abstract: Suitability of anti-erythrocyte F(ab’)2-bearing liposomes as vehicles for chloroquine in the treatment of chloroquine resistantPlasmodium berghei infections in mice has been examined. Free chloroquine or chloroquine encapsulated in antibody-free liposomes failed to show much effect on the resistant infections, but the same doses of this drug after being encapsulated in antibody-bearing liposomes exhibited a significant inhibitory effect on this infection. These results indicate that chloroquine delivery in antibody targeted liposomes may help in the successful treatment of the chloroquine resistant malarial infections.
Url:
DOI: 10.1007/BF02703366
Affiliations:
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Free chloroquine or chloroquine encapsulated in antibody-free liposomes failed to show much effect on the resistant infections, but the same doses of this drug after being encapsulated in antibody-bearing liposomes exhibited a significant inhibitory effect on this infection. These results indicate that chloroquine delivery in antibody targeted liposomes may help in the successful treatment of the chloroquine resistant malarial infections.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><country name="Inde"><noRegion><name sortKey="Chandra, Subhash" sort="Chandra, Subhash" uniqKey="Chandra S" first="Subhash" last="Chandra">Subhash Chandra</name></noRegion><name sortKey="Agrawal, Ajay K" sort="Agrawal, Ajay K" uniqKey="Agrawal A" first="Ajay K." last="Agrawal">Ajay K. Agrawal</name><name sortKey="Gupta, C M" sort="Gupta, C M" uniqKey="Gupta C" first="C. M." last="Gupta">C. M. 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